Blar i forfatter "Schröder, Susann"

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    • Development of 8f-labeled radiotracers for pet imaging of the adenosine a2a receptor: Synthesis, radiolabeling and preliminary biological evaluation 

      Lai, Thu Hang; Schröder, Susann; Toussaint, Magali; Dukić-Stefanović, Sladjana; Kranz, Mathias; Ludwig, Friedrich-Alexander; Fischer, Steffen; Steinbach, Jörg; Deuther-Conrad, Winnie; Brust, Peter; Moldovan, Rareş-Petru (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-25)
      The adenosine A<sub>2A</sub> receptor (A<sub>2A</sub>R) represents a potential therapeutic target for neurodegenerative diseases. Aiming at the development of a positron emission tomography (PET) radiotracer to monitor changes of receptor density and/or occupancy during the A<sub>2A</sub>R-tailored therapy, we designed a library of fluorinated analogs based on a recently published lead compound ...

    • PET imaging of the adenosine A2A receptor in the rotenone-based mouse model of Parkinson’s disease with [18F]FESCH synthesized by a simplified two-step one-pot radiolabeling strategy 

      Schröder, Susann; Lai, Thu Hang; Toussaint, Magali; Kranz, Mathias; Chovsepian, Alexandra; Shang, Qi; Dukić-Stefanović, Sladjana; Deuther-Conrad, Winnie; Teodoro, Rodrigo; Wenzel, Barbara; Moldovan, Rareş-Petru; Pan-Montojo, Francisco; Brust, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-02)
      The adenosine A<sub>2A</sub> receptor (A<sub>2A</sub>R) is regarded as a particularly appropriate target for non-dopaminergic treatment of Parkinson’s disease (PD). An increased A<sub>2A</sub>R availability has been found in the human striatum at early stages of PD and in patients with PD and dyskinesias. The aim of this small animal positron emission tomography/magnetic resonance (PET/MR) imaging ...